Science News 06/08

Artificial sweeteners linked to weight gain
Cutting the connection between sweets and calories may confuse the body, making it harder
to regulate intake
http://www.chemie.de/news/e/77784/

Proteinfaltung verändert das Wasser in der Umgebung
Neue Erkenntnisse der Terahertz-Spektroskopie
http://www.bionity.com/news/d/77586/

Rice scientists make breakthrough in single-molecule sensing
Simultaneous optical and electronic measurements on same molecule
http://www.chemie.de/news/e/77661/

MIT reveals superconducting surprise
A better understanding of material could bring ‚endless applications‘
http://www.chemie.de/news/e/77917/

Science News 47/07

Einwurf

Noch ein Nachzügler aus dem letzten Jahr. Ist noch etwas Weihnachtlich angehaucht, aber nachher kommt gleich der aktuelle, versprochen.

Einwurf Ende

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Science News 44/07

• Einwurf

Wie man sieht, habe ich hier noch eine SN aus dem letzten Jahr, die ich vergessen hatte. Insgesamt habe ich noch 3 weitere, die ich noch nicht geschickt habe und zwar die SN 47/07, 01/08 und die 02/08. Die werde ich die nächsten Tage nachliefern.

• Einwurf Ende

Radar Technology Fights Breast Cancer
http://www.bio.com/newsfeatures/newsfeatures_research.jhtml?cid=35200001
microwave hyperthermia on top of neoadjuvant chemotherapy shrunk tumors about 50% more
than with chemotherapy alone.

Merck Suspends Enrollment in Vertex Drug Study
http://www.bio.com/newsfeatures/newsfeatures_industry.jhtml?cid=35100005
Aurora kinase inhibitors for cancer treatment

Gene Therapy Trial Resumes after Patient Death
http://www.bio.com/newsfeatures/newsfeatures_industry.jhtml?cid=35200004
U.S. Food and Drug Administration (FDA) removed the hold on the Company’s Phase I/II
clinical trial of tgACC94 for inflammatory arthritis.

‚Cocktail‘ of Compounds Improves Brain Function in Rodents
http://www.bio.com/newsfeatures/newsfeatures_research.jhtml?cid=35200007
cocktail of DHA (a type of omega-3 fatty acid), uridine and choline increases
concentration of dendritic spines in rodents. Potential for Alzheimer disease treatment

Europe to Tackle Brain Disorder Research
http://www.bio.com/newsfeatures/newsfeatures_research.jhtml?cid=35200006
Project to exploit recent advances in PET (Positron Emission Tomography), and SPECT
(Single Photon Emission Computer Tomography).

Advances Made in Predicting Crystal Structures
Findings of international test have implications for pharmaceutical development
http://www.bio.com/newsfeatures/newsfeatures_research.jhtml?cid=35200008
predicting the crystal structures of small organic molecules by computational methods
without experimental input

ES Cell International Announces Production of World’s First Clinical-Grade Stem Cell Lines
http://www.bio.com/newsfeatures/newsfeatures_industry.jhtml?cid=35200011

Genedata Provides Expressionist Platform to U.S. Food and Drug Administration
http://www.bio.com/newsfeatures/newsfeatures_industry.jhtml?cid=35200003

Identification of Proteins Key to Brain Function
http://www.bio.com/newsfeatures/newsfeatures_research.jhtml?cid=35100007
Ena/VASP

DOE JGI Plumbs Termite Guts to Yield Novel Enzymes for Better Biofuel Production
http://www.bio.com/newsfeatures/newsfeatures_research.jhtml?cid=35100009

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Science News 46/07

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Science News 43/07

Einwurf

Und wieder kommen die neuen Science News von Doc Grey

Einwurf Ende

Rules-Based Medicine Awarded $849,000 Grant by the National Institutes of Health
http://www.bio.com/newsfeatures/newsfeatures_industry.jhtml?cid=35100004
Fast-Track” grant for the development of a diagnostic test for neonatal sepsis

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Science News 42/07

Non-Invasive Method to Track Nerve-Cell Development in Live Human Brain
http://www.bio.com/newsfeatures/newsfeatures_research.jhtml?cid=35000001
First biomarker that permits neural stem and progenitor cells (NPCs) to be tracked by
MRI; Diagnostic Applications Foreseen in Cancer, Neurological and Psychiatric Illnesses

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Science News 40/07

New Genetic Variant Associated with Prostate Cancer in African Americans
http://www.bio.com/newsfeatures/newsfeatures_research.jhtml?cid=34800009
8q24 locus: DNA repair gene is involved

First Interdisciplinary Prostate Cancer Congress
http://www.bio.com/newsfeatures/newsfeatures_research.jhtml?cid=34800004

Santaris Pharma’s HIF-1 Alpha Antagonist Begins Second Phase 1 Study Against Solid
Tumours and Lymphoma
http://www.bio.com/newsfeatures/newsfeatures_industry.jhtml?cid=34900001
RNA-targeted drug based on Santaris Pharmas Locked Nucleic Acid (LNA) technology

Fine-tuning Lasers to Destroy Blood-borne Diseases Like AIDS
http://www.bio.com/newsfeatures/newsfeatures_research.jhtml?cid=34900004
Impulsive Stimulated Raman Scattering (ISRS), produces lethal vibrations in the protein
coat of microorganisms, thereby destroying them.

Roche Diagnostics‘ HIV Viral Load Test Used in Clinical Trials for Isentress, a New Class
of HIV Drug
http://www.bio.com/newsfeatures/newsfeatures_industry.jhtml?cid=34800007
COBAS(R) HIV-1 AMPLICOR viral load test. Isentress (Raltegravir) is an HIV Integrase
inhibitor.

Domestic Cat Genome Sequenced
http://www.bio.com/newsfeatures/newsfeatures_research.jhtml?cid=34800010
7th. Mammalian genome. 20285 putative genes.

Researchers Breed a Mighty Mouse
http://www.bio.com/newsfeatures/newsfeatures_research.jhtml?cid=34900005
Case Western Reserve University researchers have bred a line of “mighty mice” (PEPCK-Cmus
mice) that have the capability of running five to six kilometers at a speed of 20 meters
per minute on a treadmill for up to six hours before stopping.
They´re utilizing mainly fatty acids for energy and produce very little lactic acid.

New Designer Toxins Kill Bt-resistant Insect Pests
http://www.bio.com/newsfeatures/newsfeatures_research.jhtml?cid=34900003
Biotech cotton toxins act by Cadherin-Binding and pore formation in the gut.

MIT: Human-generated Ozone will Damage Crops
http://www.bio.com/newsfeatures/newsfeatures_research.jhtml?cid=34800005
hree environmental changes (increases in temperature, carbon dioxide and ozone)
associated with human activity will affect crops, pastures, and forests.
50 percent increase of global ozone concentration by 2100

FDA Withdraws Three Electronic Submission Guidances in Favor of eCTD
http://www.bio.com/newsfeatures/newsfeatures_industry.jhtml?cid=34800013
This new guidance becomes effecrive on December 31, 2007.

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Science News 40/07

IBA Health Completes Acquisition Of iSOFT plc
http://www.bio.com/newsfeatures/newsfeatures_industry.jhtml?cid=34800001
The unification of these two health-focused organisations will create one of the world’s
largest healthcare IT providers.

Relypsa Formed to Discover and Develop Polymeric Drugs
http://www.bio.com/newsfeatures/newsfeatures_industry.jhtml?cid=34800003
Ion binding drugs

Dr. James D. Watson Retires as Chancellor of CSHL
http://www.bio.com/newsfeatures/newsfeatures_research.jhtml?cid=34700006

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Science News 39/07

Einwurf

Nachdem ich wieder etwas ruhe habe und Doc Grey aus dem Urlaub ist, kommen mal wieder die Science News

Einwurf Ende

Researchers Discover Three New Genes that Cause Lung Cancer
http://www.bio.com/newsfeatures/newsfeatures_research.jhtml?cid=34300006
TTF1, NKX2-8, and PAX9 on Chromosome 14 mutated in 20% of lung cancers

Scientists Discover microRNA Markers for Testicular Cancer
http://www.bio.com/newsfeatures/newsfeatures_research.jhtml?cid=34500001
Scientists at the Erasmus MC-University Medical Center in Rotterdam, The Netherlands and
Applied Biosystems an Applera Corporation business, have made significant advances in
testicular cancer research by identifying and analyzing a set of specific microRNA
molecular markers that are involved in the development of testicular tumors.

MIT Works Toward Novel Therapeutic Device
http://www.bio.com/newsfeatures/newsfeatures_research.jhtml?cid=34700004
Capturing of circulating cells out of the blood stream using cell rolling signal mechanism
PEG-coated glass slides doted with P-selectin.

Paving the Way for Future Pan-European Clinical Trials
http://www.bio.com/newsfeatures/newsfeatures_industry.jhtml?cid=34300012
European Medical Research Council (EMRC): “Pan-European collaboration is important for
many clinical trials and essential for trials that are investigating treatments for rare
diseases” EUROCORES, EURAMOS, PROFIDYS

Treatment Blocks Pain without Disrupting other Functions
http://www.bio.com/newsfeatures/newsfeatures_research.jhtml?cid=34200002
A combination of two drugs (capsaicin; QX-314)can selectively block pain-sensing neurons
in rats without impairing movement or other sensations such as touch

Potential Treatment for Huntington’s Disease
http://www.bio.com/newsfeatures/newsfeatures_research.jhtml?cid=34300005
A small molecule drug called C2-8 appears to delay the loss of motor control and reduce
neurological damage in a mouse model

Engineers Study Brain Folding in Higher Mammals
http://www.bio.com/newsfeatures/newsfeatures_research.jhtml?cid=34200003
common ground between the shaping of the brain and the heart during embryonic development.

One Shot of Gene Therapy Spreads Through Brain in Animal Study
http://www.bio.com/newsfeatures/newsfeatures_research.jhtml?cid=34300011
By targeting a site (ventral tegmental area ) in a mouse brain well connected to other
areas, researchers successfully delivered a beneficial gene to the entire brain

Drug Cocktail Stops Brain Damage Caused by HIV
http://www.bio.com/newsfeatures/newsfeatures_research.jhtml?cid=34300007
Highly Active Anti-Retroviral Therapy (HAART)

Epstein-Barr: A Virtual Look at a Vexing Virus
http://www.bio.com/newsfeatures/newsfeatures_research.jhtml?cid=34700001
PathSim is an agent-based computer program

Antibody Leads to Repair of Myelin Sheath in Lab Study of Multiple Sclerosis and Related
Disorders
http://www.bio.com/newsfeatures/newsfeatures_research.jhtml?cid=34300008

Body-mind Meditation Boosts Performance, Reduces Stress
http://www.bio.com/newsfeatures/newsfeatures_research.jhtml?cid=34300010

Nature Leads the way for the Next Generation of Paints, Cosmetics and Holograms
http://www.bio.com/newsfeatures/newsfeatures_research.jhtml?cid=34200001
An extremely effective way of growing diatoms in controlled laboratory conditions was
found

Appendix Isn’t Useless After All
http://www.bio.com/newsfeatures/newsfeatures_research.jhtml?cid=34300004
It’s a safe house for bacteria

Statement by Cold Spring Harbor Laboratory Regarding James D. Watson
http://www.bio.com/newsfeatures/newsfeatures_research.jhtml?cid=34600001
Earlier this evening, the Cold Spring Harbor Laboratory Board of Trustees decided to
suspend the administrative responsibilities of Chancellor James D. Watson, Ph.D., pending
further deliberation by the Board. This action follows the Board’s public statement
yesterday disagreeing with the comments attributed to Dr. Watson in the October 14, 2007
edition of The Sunday Times U.K.

Science News 38/07

JILA Finds Flaw in Model Describing DNA Elasticity
http://www.bio.com/newsfeatures/newsfeatures_research.jhtml?cid=33700002

New Record for Brightness of Quantum Dots
http://www.bio.com/newsfeatures/newsfeatures_research.jhtml?cid=34000001
Enhanced fluorescence intensity by placing quantum dots on a specially designed photonic crystal

The Importance of Gene Regulation for Common Human Diseas

http://www.bio.com/newsfeatures/newsfeatures_research.jhtml?cid=33700010
A new study published in Nature Genetics on Sunday 16 September 2007 show that common, complex diseases are more likely to be due to genetic variation in regions that control activity of genes, rather than in the regions that specify the protein code.

Long-awaited International Ethical Guidelines for Biobank Researchers
http://www.bio.com/industryanalysis/industryanalysis_news.jhtml?cid=33700004

Ankyrin Repeat and Kinase Domain containing 1 Gene May Influence Alcoholism
http://www.bio.com/newsfeatures/newsfeatures_research.jhtml?cid=34000002
ANKK1

Vitamin E Trials ‚Fatally Flawed‘
http://www.bio.com/newsfeatures/newsfeatures_research.jhtml?cid=33900001
levels of VIT E necessary to reduce oxidative stress are far higher than those that have
been commonly used in clinical trials so far.

Genes Controlling Female Fertility Identified
http://www.bio.com/newsfeatures/newsfeatures_research.jhtml?cid=33900002
nearly 350 genes related to female fertility found in FOXO3 knockout mice.

Genetic Variant Linked to Odor Perception
http://www.bio.com/newsfeatures/newsfeatures_research.jhtml?cid=33700009

Scientists Synthesize Memory in Yeast Cells
http://www.bio.com/newsfeatures/newsfeatures_research.jhtml?cid=33700006
Synthetic biology

A Molecule that Protects from Neuronal Disorders
http://www.bio.com/newsfeatures/newsfeatures_research.jhtml?cid=33700005
n-cofilin: oranizing cell skeleton

Revealing the workings of ‚Mother Nature’s blowtorch‘
http://www.bio.com/newsfeatures/newsfeatures_research.jhtml?cid=33700003
Structure details of Cy P450 – Cy b5 complex.

Possible Safer Target for Anti-clotting Drugs Found
http://www.bio.com/newsfeatures/newsfeatures_research.jhtml?cid=34000008
PTP1B. Also for Diabetes and obesity.

Zell-basierte In-vitro-Testplattform
http://www.bionity.com/news/d/70811/
Am Fraunhofer IBMT wurde eine In-vitro-Testplattform entwickelt, die auch ein Modul zur nichtinvasiven (zerstörungsfreien) Charakterisierung von kleinsten 3-D-Gewebeproben mittels Impedanzspektroskopie und Potenzialableitung enthält.

Toward a Faster Prenatal Test for Down Syndrome
http://www.bio.com/newsfeatures/newsfeatures_research.jhtml?cid=33700013
Digital PCR for Chromosome amplification analysis.

Discovery Supports Theory of Alzheimer’s Disease as Form of Diabetes
http://www.bio.com/newsfeatures/newsfeatures_research.jhtml?cid=34000007
ADDL (amyloid ?-derived diffusible ligand) removes Insulin receptors from brain cells.

A Possible Key to Autoimmune Disease
http://www.bio.com/newsfeatures/newsfeatures_research.jhtml?cid=33700012
LL37 or CAMP and it´s association with autoimmune disease

New Nanoparticle Vaccine is more Effective but less Expensive
http://www.bio.com/newsfeatures/newsfeatures_research.jhtml?cid=33700008

Mechanism for the in-vivo Transport of siRNA
http://www.bio.com/newsfeatures/newsfeatures_research.jhtml?cid=33700007
HDL or LDL bound Cholesterol-siRNA constructs.

Linchpin Gene May be Useful Target for New Breast Cancer Therapies
http://www.bio.com/newsfeatures/newsfeatures_research.jhtml?cid=33700001
Silencing of TFAP2C leads to reduction of ER-alpha and GPR30 in estrogen responsive breast cancer.

Study Suggests Brain Tumors Need Treatment with Multiple ‚Targeted‘ Drugs
http://www.bio.com/newsfeatures/newsfeatures_research.jhtml?cid=33500019
3 or more RTKs are are simultaneously activated in diverse brain cancer cell lines, therefore demanding multiple RTK inhibitors.
The kinase inhibitor imatinib (Gleevec) had little effect on the errant signaling pathways when applied to the brain tumor cells. But when imatinib was given in combination with two other kinase inhibitors, erlotinib (Tarceva) and SU11274, traffic in the PI3K signaling pathway was eliminated, and the cancer cells died

Molecular Profiling Can Accurately Predict Survival in Colon Cancer Patients
http://www.bio.com/newsfeatures/newsfeatures_research.jhtml?cid=34000006
researchers identified a subset of 100 genes that were able to predict outcome equally as well as the full-genome molecular expression profile. Many of these genes are know to regulate the Epithelial-Mesenchymal transition (EMT)

T vs. B: Re-engineered Human T Cells Effectively Target and Kill Cancerous B Cells
http://www.bio.com/newsfeatures/newsfeatures_research.jhtml?cid=33700014
T-cells expressing 19-28z: A chimeric antigen receptor against CD19

Fruits and Veggies not likely Linked to Colon Cancer Risk
http://www.bio.com/newsfeatures/newsfeatures_research.jhtml?cid=34000004
But there may be a lower risk of cancer of the distal colon in the left-hand side of the colon

Scientists Discover How Cancer May Take Hold
http://www.bio.com/newsfeatures/newsfeatures_research.jhtml?cid=34000003
Cancer Cells are converting tryptophane to kynurenine by IDO and transport it outside of the cells with LAT1 therefore inhibiting T-cells in a double manner.

Targeting Nerve Growth Factor may Cure Liver Cancer
http://www.bio.com/newsfeatures/newsfeatures_research.jhtml?cid=33800001
NGF and its receptor trkANGF overexpressid in liver cirrhosis and HCC

Pathway to Cell Death Redefined
http://www.bio.com/newsfeatures/newsfeatures_research.jhtml?cid=33800002
Role of SRP-6 (a protease inhibitor) in necrosis.

Die neue Ausgabe des karriereführer naturwissenschaften jetzt erhältlich
http://www.karrierefuehrer.de/publikationen/bestellung.html